What is Ketosis?

Confused by Ketones, Ketosis, Ketogenic Diet, Keto?  Fear Not!

Kent, C, Kesl SL, Hodges SA, Nations L. KetoPet Sanctuary:ketosis, cancer, and canines part 1. Innovative Veterinary Care Journal. 2019;9(2):32-37.  

*What is Ketosis?

In the modern canine diet, the dominant fuel for the body is sugar/glucose metabolized from carbohydrates. To survive in varied conditions, all living beings are physiologically adapted to use more than one form of fuel: glucose and ketones. During fasting, starvation, vigorous exercise, and caloric restriction (when blood glucose is low,) the metabolism naturally shifts towards the breakdown of fat into usable energy, called ‘ketone bodies,’ or ‘ketones’ This fat can be derived directly from the diet or adipose tissue stored throughout the body (aka body fat.) 

The lowering of glucose plus the elevation of ketones in the blood produces the healthy and natural metabolic state called ketosis. It was once believed that dogs could not achieve ketosis; however, modern research shows that dogs do enter ketosis, though it may take longer to achieve. Blood glucose levels tend to lower at the same rate as humans on the diet; however, blood ketone levels do not elevate as high compared to humans. 

At KetoPet, our nonprofit partner, they observed an overall average blood glucose level of 62.7 mg/dL and blood ketone level of 0.7 mM BHB. Some medications, like prednisone, can spike blood glucose, making it challenging for a dog to enter into ketosis. 

What is a Ketogenic Diet? 

A ketogenic diet (KD) is a nutritional strategy that intentionally manipulates the macronutrient ratio of carbohydrates, fats, and proteins to induce a state of ketosis. The average American doggo diet (kibble) is greater than 45% carbohydrate. The KD shifts the carbohydrate component to less than 10% and increases fats to 60-80% of total daily calories. Thus, a KD is high in fat, adequate in protein, and low in carbohydrates. 

For our doggos, a KD can range from 69%-90% fat, 17%-9% protein, and 1% carbohydrates, depending on the dog and purpose. KD’s with higher percentage fats (87% +) are favored for seizure control in dogs with epilepsy; however, these higher percentages are not needed to induce ketones, nor do they appear to significantly increase ketone levels in the blood. KetoPet observed that dogs routinely entered ketosis using an 82% fat/ 17% protein/ 1% formulation. 

After a period of time (120-days minimum), dogs may be able to maintain ketosis on a lower formulation (69% fat/17% protein/1% carbohydrates) allowing for more protein intake however, each dog was different. Optimization of carbohydrate and protein intake must be validated through dietary monitoring, dietary modification, and ketone and glucose testing to determine what works best for each dog. 

As compared to other low carb diets, like Atkins, the KD requires only adequate protein. Like carbohydrates, the body can convert excess protein into sugar, thus disabling ketogenesis. Commercially packaged dog foods can contain up to 80% of calories from carbohydrates. Nutritional facts panels on pet foods do not list carbohydrates (or sugars for that matter), which makes it difficult to determine how much digestible carbs a product contains without sending it to a lab for detailed analysis. Even products that claim to be grain-free can still contain high amounts of carbs in the form of fruit, root veggies, added sugars or fructose, soy and pea tapioca & potato flour's Therefore, all processed kibble diets are too high in carbohydrates to induce ketosis. 

In implementing a Ketogenic Diet in dogs, some commercially available food products, or a meticulous home-made diet, can allow pet owners to implement the Ketogenic Diet at home. The math required to calculate the meal plan at home, however, can be daunting. KetoPet has created a free eBook and online keto calculator that helps pet parents formulate ketogenic meal plans for their doggos. KetoPet

Despite the clear therapeutic potential of the KD, the success of KetoPet is largely attributed to strict protocols that were followed. I am not suggesting pet owners follow all the protocols of KetoPet, unless you have a staff of veterinarians and vet techs at home! But, The KD can contribute to success at home when protocols and adjunctive therapies are implemented consistently. Following are some examples:

  • Engaging your veterinarian as your partner in your doggos keto journey 
  • Elimination of carbohydrates and glucose sources found in non-keto foods and treats
  • Repeated blood glucose and ketone testing at home or by your veterinarian
  •  Dietary adjustments based on glucose/ketone results and canine body composition  
  • 20-30 minutes of metabolic conditioning twice daily. Daily exercise increases heart rate and burns calories 
  • Use of standard of care when deemed appropriate by your veterinary
Common Ketogenic Diet Myths:

"The keto diet is too expensive". The wonderful thing about partnering with  KetoPet is that they have a free calculator you can use that will give you a keto recipe you can make at home. This makes feeding keto affordable. On those days, where you are pressed for time or traveling, you can use a pre-packaged keto food.

 “The diet is unpalatable.” Fats contain more calories per gram of food. Therefore, less volume must be consumed to attain satiety. The decreased need for volume is often perceived as appetite loss or disdain for the diet. 


“High fat causes pancreatitis.” Oxidized phospholipids (oxPLs) accumulate at sites of inflammation and are involved in a wide range of inflammatory diseases. Combined with anti-nutrients and heat, lipid compounds can generate a massive neutrophil infiltration within necrotic areas of peripancreatic adipose tissue, thus aggravating pancreatic conditions. 

Processed kibble diets are extensively heated, high in glucose, and high in antinutrients, meeting all the parameters of pancreatic stress. Adding fat from fresh food sources may then push an already struggling pancreas over the edge. Despite the thought that high-fat diets in dogs often leads to pancreatitis this is rarely, if ever, the case with a natural KD. Natural, unprocessed fats are easily digestible in a normal, healthy canine intestinal tract. 

“High fat causes diarrhea and vomiting.” Dietary transitions commonly cause digestive detox, particularly when transitioning from processed to fresh foods. Digestive upset regurgitation, and occasional loose stool or diarrhea can occur as a result of positive changes in the gut microbiome and intestinal bacterial population when starting a different macronutrient profile diet. A quality probiotic, fiber source, or digestive enzyme supplement can assist the transition.


“It causes excessive weight loss.” KDs cause a purging of excessive water stores, loss of white fat and gain in brown fat, thus altering body composition. Loss of retained water (sometimes as much as 10-15% of body weight) is sometimes perceived as excessive weight loss. Rigorous weight monitoring and dietary adjustments prevent excessive weight loss.

 “The KD causes constipation.” Loss of excessive water stores causes losses in electrolytes. A lack of appropriate electrolyte supplementation can potentially lead to side effects.

“The KD can cause fatty liver disease.” Deterioration of hepatic function can result in abnormal bile flow and accumulation of toxins in the bloodstream. High fat consumption does not cause hepatic deterioration. However, a KD may exacerbate previously diagnosed fatty liver conditions. 

“The KD causes ketoacidosis.” When there is a resistance to normal hormonal controls, blood glucose levels rocket above 300mg/dL. Alternatively, ketosis or fasting results in glucose levels averaging 50-100mg/dL. Additionally, ketoacidosis causes the body to uncontrollably produce ketones, with levels reaching 15-25mM vs the maximum of 7mM induced by ketosis.

 “Fats increase cholesterol, triglyceride and atherosclerosis risk.” The majority of recent studies have suggested that the KD can lead to significant benefits in biomarkers of metabolic health, including blood lipid profiles. In these studies, the KD positively altered blood lipids, decreasing total triglycerides and cholesterol while increasing the ratio of HDL to LDL. Pet owners must understand that even a small quantity of carbohydrates, excess protein, or overfeeding can rapidly inhibit ketosis. Furthermore, enhanced ketone production and utilization can take up to several weeks (keto-adaptation.) 

Until next time,

Waggy Tails!

Visionary Pet. 

SMART DOGS 

EAT

LOW CARB

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